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Well-differentiated liposarcoma

3 associated genes
4 signs/symptoms

PROTEIN INTERACTIONS: 1

Isolated 3-methylcrotonyl-CoA carboxylase deficiency

2 OMIM references -
2 associated genes
10 signs/symptoms

Well-differentiated liposarcoma

Isolated 3-methylcrotonyl-CoA carboxylase deficiency

CDK4	(UniProt - OMIM)		MCCC1	(UniProt - OMIM)
HMGA2	(UniProt - OMIM)		MCCC2	(UniProt - OMIM)
MDM2	(UniProt - OMIM)


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	MDM2	(0.63)	MCCC2

Citations in the biomedical literature:

Well-differentiated liposarcoma		Isolated 3-methylcrotonyl-CoA carboxylase deficiency
	Synonym(s): - ALT - Atypical lipoma - Atypical lipomatous tumor - WDLS		Synonym(s): - 3-methylcrotonylglycinuria - MCC deficiency - MCCD

	Classification (Orphanet): - Rare oncologic disease		Classification (Orphanet): - Inborn errors of metabolism - Rare genetic disease

	Classification (ICD10): - Neoplasms -		Classification (ICD10): - Endocrine, nutritional and metabolic diseases -

	Epidemiological data: Class of prevalence: unknown Average age onset: adulthood Average age of death: adult Type of inheritance: sporadic		Epidemiological data: Class of prevalence: unknown Average age onset: neonatal/infancy Average age of death: - Type of inheritance: autosomal recessive

	External references: No OMIM references No MeSH references		External references: 2 OMIM references - 1 MeSH reference: C535308

Well-differentiated liposarcoma		Isolated 3-methylcrotonyl-CoA carboxylase deficiency
	Very frequent - Soft tissue sarcoma / cancer / tumor / liposarcoma / myosarcoma - Subcutaneous nodules / lipomas / tumefaction / swelling Occasional - Functional anomalies of the kidney and the urinary tract - Intestinal transit disorder		Very frequent - Hypoglycemia - Hypotonia - Metabolic anomalies - Organic acid metabolism anomalies Frequent - Failure to thrive / difficulties for feeding in infancy / growth delay - Hyperammonemia - Movement disorder Occasional - Cerebral vascular anomalies - Hypertonia / spasticity / rigidity / stiffness - Respiratory distress / dyspnea / respiratory failure / lung volume reduction